Endocrine Abstracts

Long-term sequels of pituitary radiotherapy include hypopituitarism, optic nerve atrophy, sensorineural hearing loss, neurocognitive impairment and second intracranial neoplasms, the meningioma being the most frequent. The cumulative incidence of second cerebral tumours within 20 years of the radiation is 2% and, unlike its primary forms, they show a more aggressive atypical histology, and the age of appearance varies depending on the latency time, which in its turn is proport...

Introduction: Medullary thyroid carcinoma (MTC) is a neuroendocrine tumour that arises from c cells of the thyroid gland and accounts for less than 8% of thyroid neoplasms. Some are familiar (MEN 2 syndrome) but most are sporadic. Genetic tests have improved the outcome in hereditary forms, but survival in sporadic MTC has not increased in last years. In most patients with sporadic MTC the disease has already metastasized at the time of diagnosis.Objecti...